Pseudomonas aeruginosa PAO1, PA5098 (hutH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003994 aconitate hydratase activity

Biological Process GO:0006548 histidine catabolic process
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 4290562 Reviewed by curator
Molecular Function GO:0004397 histidine ammonia-lyase activity
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 4290562 Reviewed by curator
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF48557
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00229
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004397 histidine ammonia-lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00229
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006548 histidine catabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00229
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00340 Histidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc HISDEG-PWY L-histidine degradation I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR10362 HISTIDINE AMMONIA-LYASE IPR001106 Aromatic amino acid lyase 5 458 6.5E-123
Gene3D G3DSA:1.10.275.10 - IPR024083 Fumarase/histidase, N-terminal 2 196 1.6E-68
NCBIfam TIGR01225 JCVI: histidine ammonia-lyase IPR005921 Histidine ammonia-lyase 4 507 0.0
FunFam G3DSA:1.20.200.10:FF:000003 Histidine ammonia-lyase - - 197 505 0.0
Gene3D G3DSA:1.20.200.10 Fumarase/aspartase (Central domain) - - 197 508 1.3E-127
Coils Coil Coil - - 293 313 -
Hamap MF_00229 Histidine ammonia-lyase [hutH]. IPR005921 Histidine ammonia-lyase 2 503 44.871258
CDD cd00332 PAL-HAL IPR001106 Aromatic amino acid lyase 8 452 0.0
SUPERFAMILY SSF48557 L-aspartase-like IPR008948 L-Aspartase-like 3 505 0.0
Pfam PF00221 Aromatic amino acid lyase IPR001106 Aromatic amino acid lyase 10 469 0.0
FunFam G3DSA:1.10.275.10:FF:000005 Histidine ammonia-lyase - - 1 196 8.6E-77

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.