Pseudomonas aeruginosa PAO1, PA5541 (pyrQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004151 dihydroorotase activity
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
15278241 Reviewed by curator
Biological Process GO:0006221 pyrimidine nucleotide biosynthetic process
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
15278241 Reviewed by curator
Molecular Function GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00483
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016787 hydrolase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01979
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF51338
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae00240 Pyrimidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
PseudoCAP Pyrimidine metabolism ECO:0000037
not_recorded
PseudoCyc PWY-5686 UMP biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF51338 IPR011059 Metal-dependent hydrolase, composite domain superfamily 1 433 6.81E-25
CDD cd01318 DHOase_IIb 49 423 3.01806E-172
Gene3D G3DSA:3.20.20.140 56 412 1.7E-129
SUPERFAMILY SSF51556 IPR032466 Metal-dependent hydrolase 55 371 2.96E-91
Gene3D G3DSA:2.30.40.10 IPR011059 Metal-dependent hydrolase, composite domain superfamily 6 427 1.7E-129
Pfam PF01979 Amidohydrolase family IPR006680 Amidohydrolase-related 231 425 3.6E-6
Pfam PF01979 Amidohydrolase family IPR006680 Amidohydrolase-related 51 125 6.0E-6
ProSitePatterns PS00483 Dihydroorotase signature 2. IPR002195 Dihydroorotase, conserved site 307 318 -

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.