Pseudomonas fluorescens SBW25, PFLU3602 (dnaE2)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0003676	nucleic acid binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01336	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01902	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006260	DNA replication	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00594	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0008408	3'-5' exonuclease activity	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00594	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF02811	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG (InterPro)	00240	Pyrimidine metabolism	InterPro 5.8-49.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion	0
KEGG (InterPro)	00230	Purine metabolism	InterPro 5.8-49.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion	0

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
CDD	cd07434	PHP_PolIIIA_DnaE2	-	-	10	262	3.59163E-126
SMART	SM00481	npolultra	IPR003141	Polymerase/histidinol phosphatase, N-terminal	11	78	6.1E-11
Gene3D	G3DSA:3.20.20.140	-	-	-	3	252	2.1E-58
CDD	cd04485	DnaE_OBF	-	-	942	1020	1.05793E-20
PANTHER	PTHR32294	DNA POLYMERASE III SUBUNIT ALPHA	IPR004805	Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC	8	1019	0.0
Pfam	PF14579	Helix-hairpin-helix motif	IPR029460	DNA polymerase, helix-hairpin-helix motif	772	861	3.0E-19
SUPERFAMILY	SSF89550	PHP domain-like	IPR016195	Polymerase/histidinol phosphatase-like	9	189	6.28E-11
Hamap	MF_01902	Error-prone DNA polymerase [dnaE2].	IPR023073	DNA polymerase, error-prone	10	1030	13.660223
NCBIfam	TIGR00594	JCVI: DNA polymerase III subunit alpha	IPR004805	Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC	11	975	0.0
Pfam	PF07733	Bacterial DNA polymerase III alpha NTPase domain	IPR011708	Bacterial DNA polymerase III, alpha subunit, NTPase domain	275	529	7.9E-80
Pfam	PF17657	Bacterial DNA polymerase III alpha subunit finger domain	IPR040982	DNA polymerase III alpha subunit finger domain	532	698	1.7E-61
Pfam	PF01336	OB-fold nucleic acid binding domain	IPR004365	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type	940	1000	1.7E-6
Pfam	PF02811	PHP domain	IPR004013	PHP domain	12	126	7.3E-14
Gene3D	G3DSA:1.10.150.870	-	-	-	761	849	9.7E-9

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.