Pseudomonas aeruginosa UCBPP-PA14, PA14_15030 (leuA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00682
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003852 2-isopropylmalate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08502
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009098 leucine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08502
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
NCBIfam TIGR00970 JCVI: 2-isopropylmalate synthase IPR005668 2-isopropylmalate synthase 43 584 0.0
CDD cd07942 DRE_TIM_LeuA IPR039371 LeuA, N-terminal catalytic TIM barrel domain 69 351 0.0
SUPERFAMILY SSF89000 post-HMGL domain-like - - 424 473 1.37E-13
Pfam PF00682 HMGL-like IPR000891 Pyruvate carboxyltransferase 69 349 7.8E-79
SUPERFAMILY SSF110921 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain IPR036230 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily 479 583 2.22E-33
Pfam PF08502 LeuA allosteric (dimerisation) domain IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 458 583 9.0E-29
SUPERFAMILY SSF51569 Aldolase - - 58 366 1.83E-98
PANTHER PTHR46911 - - - 38 590 0.0
Hamap MF_00572 2-isopropylmalate synthase [leuA]. IPR005668 2-isopropylmalate synthase 44 585 54.365555
FunFam G3DSA:3.20.20.70:FF:000045 2-isopropylmalate synthase - - 47 412 0.0
SMART SM00917 LeuA_dimer_2 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 458 584 7.7E-31
FunFam G3DSA:3.30.160.270:FF:000006 2-isopropylmalate synthase - - 413 583 2.2E-73
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 48 412 0.0
Gene3D G3DSA:3.30.160.270 - IPR036230 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily 413 583 6.4E-56

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.