Pseudomonas aeruginosa UCBPP-PA14, PA14_17260 (dnaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008408 3'-5' exonuclease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR32294
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006260 DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR32294
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003676 nucleic acid binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01336
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02811
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau03440 Homologous recombination 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00240 Pyrimidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau03030 DNA replication 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau03430 Mismatch repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:1.10.150.870 - - - 713 887 2.1E-22
SMART SM00481 npolultra IPR003141 Polymerase/histidinol phosphatase, N-terminal 6 73 2.8E-25
Gene3D G3DSA:2.40.50.140 - IPR012340 Nucleic acid-binding, OB-fold 994 1087 2.2E-6
Pfam PF02811 PHP domain IPR004013 PHP domain 7 171 1.3E-38
CDD cd07433 PHP_PolIIIA_DnaE1 - - 4 280 0.0
FunFam G3DSA:1.10.150.870:FF:000001 DNA polymerase III subunit alpha - - 714 887 3.2E-88
CDD cd04485 DnaE_OBF - - 1009 1091 2.16831E-27
Pfam PF17657 Bacterial DNA polymerase III alpha subunit finger domain IPR040982 DNA polymerase III alpha subunit finger domain 562 736 5.9E-67
PANTHER PTHR32294 DNA POLYMERASE III SUBUNIT ALPHA IPR004805 Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC 1 1168 0.0
Pfam PF01336 OB-fold nucleic acid binding domain IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 1009 1083 8.7E-10
Pfam PF07733 Bacterial DNA polymerase III alpha NTPase domain IPR011708 Bacterial DNA polymerase III, alpha subunit, NTPase domain 291 559 1.5E-102
FunFam G3DSA:1.10.10.1600:FF:000001 DNA polymerase III subunit alpha - - 434 511 3.1E-36
SUPERFAMILY SSF89550 PHP domain-like IPR016195 Polymerase/histidinol phosphatase-like 5 262 1.24E-14
Gene3D G3DSA:3.20.20.140 - - - 1 268 5.7E-95
Gene3D G3DSA:1.10.10.1600 Bacterial DNA polymerase III alpha subunit, thumb domain IPR041931 Bacterial DNA polymerase III alpha subunit, thumb domain 434 511 3.1E-26
FunFam G3DSA:3.20.20.140:FF:000028 DNA polymerase III subunit alpha - - 1 269 1.2E-128
FunFam G3DSA:2.40.50.140:FF:000106 DNA polymerase III subunit alpha - - 996 1087 4.2E-38
NCBIfam TIGR00594 JCVI: DNA polymerase III subunit alpha IPR004805 Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC 5 1045 0.0
Pfam PF14579 Helix-hairpin-helix motif IPR029460 DNA polymerase, helix-hairpin-helix motif 810 895 1.6E-25

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.