Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_43070
|
Name |
hcp2
Synonym: hcpD |
Replicon | chromosome |
Genomic location | 3831886 - 3832404 (+ strand) |
Transposon Mutants | 2 transposon mutants in UCBPP-PA14 |
Transposon Mutants in orthologs | 3 transposon mutants in orthologs |
Comment | Hcp Secretion Island-II-encoded type VI secretion system (H2-T6SS) |
RefSeq | YP_791591.1 |
GI | 116049604 |
Entrez | 4381812 |
NCBI Locus Tag | PA14_43070 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Hcp2
|
Synonyms |
secreted protein Hcp |
Evidence for Translation | |
Charge (pH 7) | -5.88 |
Kyte-Doolittle Hydrophobicity Value | -0.449 |
Molecular Weight (kDa) | 19.1 |
Isoelectric Point (pI) | 5.76 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3HE1 | structural genomics, unknown function | 05/07/09 | Secreted protein Hcp3 from Pseudomonas aeruginosa. | Pseudomonas aeruginosa | 2.098 | X-RAY DIFFRACTION | 100.0 |
Source 1 | |
Database | PseudoCAP |
Category | Hcp secretion island-2 encoded type VI secretion system (H2-T6SS) |
Evidence |
ECO:0000316
genetic interaction evidence used in manual assertion
|
Host Organism | Mus musculus |
Notes | |
Infection model | Mouse burn Infection model |
Infection model | Mouse acute lung Infection model |
Reference | 19497948 |
Source 2 | |
Database | PseudoCAP |
Category | Hcp secretion island-2 encoded type VI secretion system (H2-T6SS) |
Evidence |
ECO:0000316
genetic interaction evidence used in manual assertion
|
Host Organism | Arabidopsis thaliana |
Notes | |
Infection model | Arabidopsis leaf infiltration model |
Reference | 19497948 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 67 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000260 (995 members) |
Putative Inparalogs |
1 predicted inparalogs secreted protein Hcp (PA14_69560) 100.0% identity |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_43070
Search term: hcp2
Search term: Hcp2
|
Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis.
Lesic B, Starkey M, He J, Hazan R, Rahme LG
Microbiology (Reading) 2009 Sep;155(Pt 9):2845-2855
PubMed ID: 19497948
|
The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells.
Sana TG, Hachani A, Bucior I, Soscia C, Garvis S, Termine E, Engel J, Filloux A, Bleves S
J Biol Chem 2012 Aug 3;287(32):27095-105
PubMed ID: 22665491
|
An rhs gene linked to the second type VI secretion cluster is a feature of the Pseudomonas aeruginosa strain PA14.
Jones C, Hachani A, Manoli E, Filloux A
J Bacteriol 2014 Feb;196(4):800-10
PubMed ID: 24317402
|
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999
|