Pseudomonas aeruginosa UCBPP-PA14, PA14_68730 (gshA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006750 glutathione biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00578
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004357 glutamate-cysteine ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00578
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF55931
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class
Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc ergothioneine biosynthesis I (bacteria) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pau00480 Glutathione metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00270 Cysteine and methionine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc ophthalmate biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc homoglutathione biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF55931 Glutamine synthetase/guanido kinase IPR014746 Glutamine synthetase/guanido kinase, catalytic domain 8 514 0.0
NCBIfam TIGR01434 JCVI: glutamate--cysteine ligase IPR006334 Glutamate--cysteine ligase, monofunctional 6 517 0.0
PANTHER PTHR38761 GLUTAMATE--CYSTEINE LIGASE IPR006334 Glutamate--cysteine ligase, monofunctional 1 520 0.0
Gene3D G3DSA:3.30.590.20 - - - 21 523 0.0
Pfam PF04262 Glutamate-cysteine ligase IPR007370 Glutamate--cysteine ligase 10 378 0.0
Hamap MF_00578 Glutamate--cysteine ligase [gshA]. IPR006334 Glutamate--cysteine ligase, monofunctional 1 527 229.058502
FunFam G3DSA:3.30.590.20:FF:000007 Glutamate--cysteine ligase - - 21 523 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.