Pseudomonas aeruginosa PA7, PSPA7_0493 (proC)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0006561	proline biosynthetic process	ISS Inferred from Sequence or Structural Similarity Term mapped from: PseudoCAP:PA0393	ECO:0000249 sequence similarity evidence used in automatic assertion	8479442
Molecular Function	GO:0004735	pyrroline-5-carboxylate reductase activity	ISS Inferred from Sequence or Structural Similarity Term mapped from: PseudoCAP:PA0393	ECO:0000249 sequence similarity evidence used in automatic assertion	8479442
Molecular Function	GO:0004735	pyrroline-5-carboxylate reductase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF000193	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006561	proline biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF000193	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PA7 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
MetaCyc		L-proline biosynthesis II (from arginine)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	pap01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pap01230	Biosynthesis of amino acids	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pap01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pap00330	Arginine and proline metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pap01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		L-proline biosynthesis III	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
MetaCyc		L-ornithine degradation II (Stickland reaction)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Pfam	PF03807	NADP oxidoreductase coenzyme F420-dependent	IPR028939	Pyrroline-5-carboxylate reductase, catalytic, N-terminal	5	99	2.7E-23
FunFam	G3DSA:1.10.3730.10:FF:000001	Pyrroline-5-carboxylate reductase	-	-	166	270	1.6E-34
Hamap	MF_01925	Pyrroline-5-carboxylate reductase [proC].	IPR000304	Pyrroline-5-carboxylate reductase	4	267	27.789879
SUPERFAMILY	SSF48179	6-phosphogluconate dehydrogenase C-terminal domain-like	IPR008927	6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily	162	270	1.87E-35
Pfam	PF14748	Pyrroline-5-carboxylate reductase dimerisation	IPR029036	Pyrroline-5-carboxylate reductase, dimerisation domain	163	267	1.3E-37
Gene3D	G3DSA:3.40.50.720	-	-	-	3	164	3.0E-53
SUPERFAMILY	SSF51735	NAD(P)-binding Rossmann-fold domains	IPR036291	NAD(P)-binding domain superfamily	5	160	1.16E-38
PANTHER	PTHR11645	PYRROLINE-5-CARBOXYLATE REDUCTASE	-	-	5	270	1.6E-73
NCBIfam	TIGR00112	JCVI: pyrroline-5-carboxylate reductase	IPR000304	Pyrroline-5-carboxylate reductase	6	267	1.3E-78
FunFam	G3DSA:3.40.50.720:FF:000105	Pyrroline-5-carboxylate reductase	-	-	1	164	5.6E-60
PIRSF	PIRSF000193	P5CR	IPR000304	Pyrroline-5-carboxylate reductase	3	270	1.7E-83
Gene3D	G3DSA:1.10.3730.10	-	-	-	165	271	3.5E-40

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.