Pseudomonas aeruginosa M18, PAM18_0549 (tktA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF52922
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004802 transketolase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00232
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Energy metabolism Other M18 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG paf01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG paf01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG paf00030 Pentose phosphate pathway 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG paf01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG paf01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG paf01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG paf01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SMART SM00861 Transket_pyr_3 IPR005475 Transketolase-like, pyrimidine-binding domain 354 525 6.3E-70
CDD cd07033 TPP_PYR_DXS_TK_like - - 358 520 1.87319E-56
Gene3D G3DSA:3.40.50.920 - IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II 538 665 5.1E-45
PANTHER PTHR43522 TRANSKETOLASE IPR033247 Transketolase family 2 663 0.0
Pfam PF02779 Transketolase, pyrimidine binding domain IPR005475 Transketolase-like, pyrimidine-binding domain 353 525 5.9E-46
Pfam PF02780 Transketolase, C-terminal domain IPR033248 Transketolase, C-terminal domain 540 655 9.0E-16
NCBIfam TIGR00232 JCVI: transketolase IPR005478 Transketolase, bacterial-like 6 663 0.0
FunFam G3DSA:3.40.50.970:FF:000003 Transketolase - - 326 537 3.8E-91
Gene3D G3DSA:3.40.50.970 - - - 326 537 7.5E-87
Pfam PF00456 Transketolase, thiamine diphosphate binding domain IPR005474 Transketolase, N-terminal 5 333 0.0
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 347 526 2.4E-67
FunFam G3DSA:3.40.50.920:FF:000003 Transketolase - - 538 664 1.7E-50
Gene3D G3DSA:3.40.50.970 - - - 1 325 0.0
CDD cd02012 TPP_TK IPR005474 Transketolase, N-terminal 9 273 0.0
SUPERFAMILY SSF52922 TK C-terminal domain-like IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II 533 664 1.83E-42
FunFam G3DSA:3.40.50.970:FF:000004 Transketolase - - 2 325 0.0
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 5 320 1.23E-121

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.