Pseudomonas aeruginosa DK2, PADK2_01980

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006561 proline biosynthetic process
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA0393
 ECO:0000249
sequence similarity evidence used in automatic assertion		 8479442
Molecular Function GO:0004735 pyrroline-5-carboxylate reductase activity
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA0393
 ECO:0000249
sequence similarity evidence used in automatic assertion		 8479442
Biological Process GO:0006561 proline biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01925
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004735 pyrroline-5-carboxylate reductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01925
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other DK2 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pdk01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk00330 Arginine and proline metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
NCBIfam TIGR00112 JCVI: pyrroline-5-carboxylate reductase IPR000304 Pyrroline-5-carboxylate reductase 6 267 6.9E-80
Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal 5 99 3.8E-23
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 162 270 1.87E-35
FunFam G3DSA:1.10.3730.10:FF:000001 Pyrroline-5-carboxylate reductase - - 166 270 5.4E-35
Gene3D G3DSA:3.40.50.720 - - - 3 164 7.7E-54
Pfam PF14748 Pyrroline-5-carboxylate reductase dimerisation IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain 163 267 5.2E-38
Hamap MF_01925 Pyrroline-5-carboxylate reductase [proC]. IPR000304 Pyrroline-5-carboxylate reductase 4 267 27.870037
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 5 160 8.86E-40
Gene3D G3DSA:1.10.3730.10 - - - 165 271 1.8E-40
PIRSF PIRSF000193 P5CR IPR000304 Pyrroline-5-carboxylate reductase 3 270 2.7E-83
PANTHER PTHR11645 PYRROLINE-5-CARBOXYLATE REDUCTASE - - 5 270 2.9E-73
FunFam G3DSA:3.40.50.720:FF:000105 Pyrroline-5-carboxylate reductase - - 1 164 3.7E-60

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.