Pseudomonas entomophila L48, PSEEN5038 (metF)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity |
Inferred from Sequence Model
Term mapped from: InterPro:PF02219
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006555 | methionine metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:PF02219
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0009086 | methionine biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
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Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| MetaCyc | folate transformations I | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | pen00670 | One carbon pool by folate | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pen01200 | Carbon metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pen01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | folate transformations II | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | pen01120 | Microbial metabolism in diverse environments | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Gene3D | G3DSA:3.20.20.220 | - | - | - | 1 | 280 | 4.5E-92 |
| PANTHER | PTHR45754 | METHYLENETETRAHYDROFOLATE REDUCTASE | - | - | 3 | 279 | 4.0E-81 |
| Pfam | PF02219 | Methylenetetrahydrofolate reductase | IPR003171 | Methylenetetrahydrofolate reductase-like | 4 | 277 | 5.7E-89 |
| CDD | cd00537 | MTHFR | IPR003171 | Methylenetetrahydrofolate reductase-like | 7 | 277 | 1.87857E-126 |
| FunFam | G3DSA:3.20.20.220:FF:000014 | Methylenetetrahydrofolate reductase | - | - | 1 | 280 | 0.0 |
| NCBIfam | TIGR00676 | JCVI: methylenetetrahydrofolate reductase [NAD(P)H] | IPR004620 | 5,10-methylenetetrahydrofolate reductase | 7 | 278 | 6.2E-101 |
| SUPERFAMILY | SSF51730 | FAD-linked oxidoreductase | IPR029041 | FAD-linked oxidoreductase-like | 4 | 279 | 1.12E-94 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.