Pseudomonas aeruginosa PAO1, PA0439

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0439
Name
Synonym: yeiA
Synonym: dypB
Replicon chromosome
Genomic location 492080 - 493357 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249130.1
GI 15595636
Affymetrix PA0439_at
Entrez 877580
GenBank AAG03828.1
NCBI Locus Tag PA0439
protein_id(GenBank) gb|AAG03828.1|AE004481_4|gnl|PseudoCAP|PA0439
TIGR NTL03PA00440
UniProtKB Acc Q9I678
UniProtKB ID Q9I678_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
probable oxidoreductase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -10.11
Kyte-Doolittle Hydrophobicity Value -0.072
Molecular Weight (kDa) 46.1
Isoelectric Point (pI) 5.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 365 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000430 (952 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0439

Human Homologs

Ensembl 94, assembly GRCh38.p12
dihydropyrimidine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:3012]
E-value: 1.5e-05
Percent Identity: 36.0

References

cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
Yokota H, Fernandez-Salguero P, Furuya H, Lin K, McBride OW, Podschun B, Schnackerz KD, Gonzalez FJ
J. Biol. Chem. 1994 Sep;269(37):23192-6
PubMed ID: 8083224