Pseudomonas aeruginosa PAO1, PA4807 (selB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4807
Name
selB
Replicon chromosome
Genomic location 5392523 - 5394448 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253495.1
GI 15600001
Affymetrix PA4807_selB_at
Entrez 880197
GenBank AAG08193.1
INSDC AAG08193.1
NCBI Locus Tag PA4807
protein_id(GenBank) gb|AAG08193.1|AE004893_11|gnl|PseudoCAP|PA4807
TIGR NTL03PA04808
UniParc UPI00000C5E17
UniProtKB Acc Q9HV02
UniProtKB ID Q9HV02_PSEAE
UniRef100 UniRef100_Q9HV02
UniRef50 UniRef50_J3B5U8
UniRef90 UniRef90_Q9HV02

Product

Feature Type CDS
Coding Frame 1
Product Name
selenocysteine-specific elongation factor
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 4.59
Kyte-Doolittle Hydrophobicity Value -0.254
Molecular Weight (kDa) 71.0
Isoelectric Point (pI) 8.04

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004443 (421 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4807
Search term: selB

Human Homologs

Ensembl 110, assembly GRCh38.p14
Tu translation elongation factor, mitochondrial [Source:HGNC Symbol;Acc:HGNC:12420]
E-value: 3.9e-33
Percent Identity: 31.7

References

Identification of a novel translation factor necessary for the incorporation of selenocysteine into protein.
Forchhammer K, Leinfelder W, Böck A
Nature 1989 Nov 23;342(6248):453-6
PubMed ID: 2531290
Purification and biochemical characterization of SELB, a translation factor involved in selenoprotein synthesis.
Forchhammer K, Rücknagel KP, Böck A
J Biol Chem 1990 Jun 5;265(16):9346-50
PubMed ID: 2140572