Pseudomonas aeruginosa PAO1, PA5541 (pyrQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5541
Name
pyrQ
Synonym: pyrC2
Replicon chromosome
Genomic location 6233118 - 6234455 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs
Commentgene name changed from pyrC2 to pyrQ to conform with naming standards.
CommentDeletion of pyrC and pyrC2 (pyrQ) results in pyrimidine auxotrophy

Cross-References

RefSeq NP_254228.1
GI 15600734
Affymetrix PA5541_at
Entrez 878465
GenBank AAG08926.1
INSDC AAG08926.1
NCBI Locus Tag PA5541
protein_id(GenBank) gb|AAG08926.1|AE004966_8|gnl|PseudoCAP|PA5541
TIGR NTL03PA05542
UniParc UPI00000C6063
UniProtKB Acc Q9HT33
UniProtKB ID Q9HT33_PSEAE
UniRef100 UniRef100_Q9HT33
UniRef50 UniRef50_Q9HT33
UniRef90 UniRef90_Q9HT33

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydroorotase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.79
Kyte-Doolittle Hydrophobicity Value -0.162
Molecular Weight (kDa) 49.3
Isoelectric Point (pI) 7.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 586 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000432 (845 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5541
Search term: pyrQ
Search term: dihydroorotase

References

Pseudomonas aeruginosa dihydroorotases: a tale of three pyrCs.
Brichta DM, Azad KN, Ralli P, O'Donovan GA
Arch Microbiol 2004 Sep;182(1):7-17
PubMed ID: 15278241
Molecular characterization of pyrimidine biosynthesis genes from the thermophile Bacillus caldolyticus.
Ghim SY, Nielsen P, Neuhard J
Microbiology (Reading, Engl.) 1994 Mar;140 ( Pt 3)
PubMed ID: 7516791