Pseudomonas aeruginosa PAO1, PA0501 (bioF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0501
Name
bioF
Replicon chromosome
Genomic location 560808 - 562013 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249192.1
GI 15595698
Affymetrix PA0501_bioF_at
Entrez 879619
GenBank AAG03890.1
INSDC AAG03890.1
NCBI Locus Tag PA0501
protein_id(GenBank) gb|AAG03890.1|AE004487_4|gnl|PseudoCAP|PA0501
TIGR NTL03PA00502
UniParc UPI00000C5091
UniProtKB Acc Q9I617
UniProtKB ID BIOF_PSEAE
UniRef100 UniRef100_Q9I617
UniRef50 UniRef50_B3PI88
UniRef90 UniRef90_Q9I617

Product

Feature Type CDS
Coding Frame 1
Product Name
8-amino-7-oxononanoate synthase
Product Name Confidence: Class 2
Synonyms 7-KAP synthetase, L-alanine--pimelyl coA ligase
7-keto-8-amino-pelargonic acid synthetase
Evidence for Translation
Charge (pH 7) -7.16
Kyte-Doolittle Hydrophobicity Value 0.109
Molecular Weight (kDa) 42.2
Isoelectric Point (pI) 5.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 507 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000488 (551 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0501
Search term: bioF

Human Homologs

Ensembl 94, assembly GRCh38.p12
glycine C-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:4188]
E-value: 1.5e-63
Percent Identity: 39.6

References

The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon.
Otsuka AJ, Buoncristiani MR, Howard PK, Flamm J, Johnson C, Yamamoto R, Uchida K, Cook C, Ruppert J, Matsuzaki J
J. Biol. Chem. 1988 Dec;263(36):19577-85
PubMed ID: 3058702
Characterisation of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl CoA condensing enzyme.
Webster SP, Campopiano DJ, Alexeev D, Alexeeva M, Watt RM, Sawyer L, Baxter RL
Biochem. Soc. Trans. 1998 Aug;26(3):S268
PubMed ID: 9765987
The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme.
Alexeev D, Alexeeva M, Baxter RL, Campopiano DJ, Webster SP, Sawyer L
J. Mol. Biol. 1998 Nov;284(2):401-19
PubMed ID: 9813126