Pseudomonas aeruginosa PAO1, PA0904 (lysC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0904
Name
lysC
Synonym: ask
Synonym: akaB
Replicon chromosome
Genomic location 989590 - 990828 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249595.1
GI 15596101
Affymetrix PA0904_lysC_at
Entrez 878315
GenBank AAG04293.1
INSDC AAC16241.1
NCBI Locus Tag PA0904
protein_id(GenBank) gb|AAG04293.1|AE004525_1|gnl|PseudoCAP|PA0904
TIGR NTL03PA00905
UniParc UPI0000125788
UniProtKB Acc O69077
UniProtKB ID AK_PSEAE
UniRef100 UniRef100_O69077
UniRef50 UniRef50_A4VJB4
UniRef90 UniRef90_A4VJB4

Product

Feature Type CDS
Coding Frame 1
Product Name
aspartate kinase alpha and beta chain
Product Name Confidence: Class 2
Synonyms aspartokinase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.08
Kyte-Doolittle Hydrophobicity Value 0.043
Molecular Weight (kDa) 44.4
Isoelectric Point (pI) 4.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5YEI TRANSFERASE 09/17/17 Mechanistic insight into the regulation of Pseudomonas aeruginosa aspartate kinase PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PR 2.301 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 637 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000871 (547 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0904
Search term: lysC

References

Genetic and biochemical analysis of the aspartokinase from Corynebacterium glutamicum.
Kalinowski J, Cremer J, Bachmann B, Eggeling L, Sahm H, Pühler A
Mol. Microbiol. 1991 May;5(5):1197-204
PubMed ID: 1956296
Gene structure and expression of the Corynebacterium flavum N13 ask-asd operon.
Follettie MT, Peoples OP, Agoropoulou C, Sinskey AJ
J. Bacteriol. 1993 Jul;175(13):4096-103
PubMed ID: 8100567