Pseudomonas aeruginosa PAO1, PA1279 (cobU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1279
Name
cobU
Synonym: cobT
Replicon chromosome
Genomic location 1390225 - 1391280 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249970.1
GI 15596476
Affymetrix PA1279_cobU_at
DNASU PaCD00006587
Entrez 881425
GenBank AAG04668.1
INSDC AAG04668.1
NCBI Locus Tag PA1279
protein_id(GenBank) gb|AAG04668.1|AE004557_9|gnl|PseudoCAP|PA1279
TIGR NTL03PA01280
UniParc UPI00000C52E7
UniProtKB Acc Q9I465
UniProtKB ID COBT_PSEAE
UniRef100 UniRef100_Q9I465
UniRef50 UniRef50_Q9I465
UniRef90 UniRef90_Q9I465

Product

Feature Type CDS
Coding Frame 1
Product Name
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Product Name Confidence: Class 2
Synonyms cobalamin biosynthesis protein cobU
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.07
Kyte-Doolittle Hydrophobicity Value 0.219
Molecular Weight (kDa) 36.5
Isoelectric Point (pI) 6.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 304 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001226 (549 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1279
Search term: cobU

References

Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase.
Cameron B, Blanche F, Rouyez MC, Bisch D, Famechon A, Couder M, Cauchois L, Thibaut D, Debussche L, Crouzet J
J Bacteriol 1991 Oct;173(19):6066-73
PubMed ID: 1917841