Pseudomonas aeruginosa PAO1, PA2616 (trxB1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2616
Name
trxB1
Replicon chromosome
Genomic location 2959468 - 2960418 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_251306.1
GI 15597812
Affymetrix PA2616_trxB1_at
Entrez 882322
GenBank AAG06004.1
INSDC AAG06004.1
NCBI Locus Tag PA2616
protein_id(GenBank) gb|AAG06004.1|AE004690_4|gnl|PseudoCAP|PA2616
TIGR NTL03PA02616
UniParc UPI00000C576C
UniProtKB Acc Q9I0M2
UniProtKB ID Q9I0M2_PSEAE
UniRef100 UniRef100_Q9I0M2
UniRef50 UniRef50_P39916
UniRef90 UniRef90_Q9I0M2

Product

Feature Type CDS
Coding Frame 1
Product Name
thioredoxin reductase 1
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -11.26
Kyte-Doolittle Hydrophobicity Value -0.152
Molecular Weight (kDa) 33.8
Isoelectric Point (pI) 5.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 655 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000816 (902 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2616
Search term: trxB1

Human Homologs

References

Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis.
Waksman G, Krishna TS, Williams CH Jr, Kuriyan J
J Mol Biol 1994 Feb 25;236(3):800-16
PubMed ID: 8114095
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994