Pseudomonas aeruginosa DK2, PADK2_02150
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa DK2
GCF_000271365.1|latest |
| Locus Tag |
PADK2_02150
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 467199 - 470156 (+ strand) |
Cross-References
| RefSeq | YP_006480425.1 |
| GI | 392981838 |
| Entrez | 13171966 |
| NCBI Locus Tag | PADK2_02150 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
RND multidrug efflux transporter MexB
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -9.89 |
| Kyte-Doolittle Hydrophobicity Value | 0.287 |
| Molecular Weight (kDa) | 106168.1 |
| Isoelectric Point (pI) | 5.38 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2V50 | MEMBRANE PROTEIN | 10/01/08 | The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB | PSEUDOMONAS AERUGINOSA PA01 | 3 | X-RAY DIFFRACTION | 94.1 |
| 6IIA | MEMBRANE PROTEIN | 10/04/18 | MexB in complex with LMNG | Pseudomonas aeruginosa PAO1 | 2.91 | X-RAY DIFFRACTION | 94.1 |
| 3W9J | MEMBRANE PROTEIN | 04/04/13 | Structural basis for the inhibition of bacterial multidrug exporters | Pseudomonas aeruginosa | 3.15 | X-RAY DIFFRACTION | 94.1 |
| 3W9I | MEMBRANE PROTEIN | 04/04/13 | Structural basis for the inhibition of bacterial multidrug exporters | Pseudomonas aeruginosa | 2.71 | X-RAY DIFFRACTION | 94.2 |
| 6IOL | MEMBRANE PROTEIN | 10/30/18 | Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) | Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1 | 3.76 | ELECTRON MICROSCOPY | 94.2 |
| 6IOK | MEMBRANE PROTEIN | 10/30/18 | Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | Pseudomonas aeruginosa PAO1 | 3.64 | ELECTRON MICROSCOPY | 94.2 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000417 (2093 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PADK2_02150
Search term: RND multidrug efflux transporter MexB
|
Human Homologs
References
No references are associated with this feature.