Pseudomonas aeruginosa PA7, PSPA7_0457 (coaD)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PA7 GCF_000017205.1|latest
Locus Tag	PSPA7_0457
Name	coaD
Replicon	chromosome
Genomic location	466107 - 466658 (- strand)

Cross-References

RefSeq	YP_001345852.1
GI	152987438
EC Number	2.7.7.3
Entrez	5355630
INSDC	ABR84621.1
NCBI Locus Tag	PSPA7_0457
UniParc	UPI00015774DB
UniProtKB Acc	A6UYG7
UniProtKB ID	A6UYG7_PSEA7
UniRef100	UniRef100_B7V2S6
UniRef50	UniRef50_Q5ZY26
UniRef90	UniRef90_B7V2S6

Product

Feature Type	CDS
Coding Frame	1
Product Name	phosphopantetheine adenylyltransferase
Synonyms
Evidence for Translation
Charge (pH 7)	3.16
Kyte-Doolittle Hydrophobicity Value	-0.027
Molecular Weight (kDa)	20.3
Isoelectric Point (pI)	9.09

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
3X1K	TRANSFERASE	11/20/14	crystal structure of Phosphoapantetheine adenylyltransferase PPAT/CoaD with AMP-PNP from Pseudomonas aerugonosa	Pseudomonas aeruginosa 2192	2.547	X-RAY DIFFRACTION	100.0
4RUK	TRANSFERASE	11/20/14	crystal structure of Phosphoapantetheine adenylyltransferase PPAT/CoaD with CoA and pyrophosphate from Pseudomonas aeruginosa	Pseudomonas aeruginosa 2192	2.2	X-RAY DIFFRACTION	100.0
5TS2	TRANSFERASE	10/27/16	Crystal structure of a phosphopantetheine adenylyltransferase (CoaD, PPAT) from Pseudomonas aeruginosa bound to dephospho coenzyme A	Pseudomonas aeruginosa (strain LESB58)	2.3	X-RAY DIFFRACTION	100.0
3X1M	TRANSFERASE	11/24/14	Crystal structure of Phosphopantetheine adenylyltransferase/PPAT from Pseudomonas aeruginosa with CoA	Pseudomonas aeruginosa 2192	2.5	X-RAY DIFFRACTION	100.0
3X1J	TRANSFERASE	11/19/14	Crystal Structure of Phosphopantetheine adenylyltransferase (PPAT/CoaD) with AcCoA from Pseudomonas aeruginosa	Pseudomonas aeruginosa 2192	2.334	X-RAY DIFFRACTION	100.0
5X6F	TRANSFERASE	02/21/17	Crystal structure of Phosphopantetheine adenylyltransferase from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.593	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 578 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000354 (537 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPA7_0457 Search term: coaD Search term: phosphopantetheine adenylyltransferase

Human Homologs

References